We are organizing the 5th T21RS International Conference “Promoting Research Excellence in Down Syndrome” in Rome from the 5th to the 8th of June 2024.


Down syndrome (DS) arises from the inheritance of three copies of chromosome 21, known as trisomy 21. The DS phenotype involves manifestations that affect multiple bodily systems including the musculoskeletal, neurological and cardiovascular systems. The remarkable advancements in DS research over the past decade underscore the crucial necessity for effective communication among scientists, clinicians, families, and self-advocates. Trisomy 21 Research Society (T21RS) is the first international non-profit scientific organization of researchers studying Down syndrome. The establishment of the T21RS in 2014 represented a significant milestone in the field of Down syndrome research signifying the critical mass reached by the international community in this field. The primary goal of T21RS is supporting the dissemination and discussion of the latest advances in clinical and preclinical research in this field through its biennial meeting series. T21RS aims to facilitate collaboration among researchers and utilize new scientific knowledge to develop improved treatments and potential cures. Translating basic scientific discoveries into effective treatments for individuals with Down syndrome is a significant challenge that unifies researchers, families, and clinicians. Additionally, T21RS focuses on harmonizing protocols for (pre)clinical research, supporting education and training for young researchers. The next T21RS meeting will be held in Rome, June 5 to 8, 2024 at both Sapienza University of Rome (opening) and at “La Nuvola” Rome congress center. We expect more than 500 participants from around the world. In this edition we are establishing new ambitious programs for well- known DS and non-DS investigators, but also for national and international DS associations and families. The themes of the next T21Rs conference includes Genomic and epigenetic mechanisms; Molecular and Cellular Mechanisms; Experimental models; Cognition and Behavior; Neurodegeneration and Ageing; Neurodevelopment; Co-occurring Illnesses; Therapeutic intervention; Diagnosis and Evaluation; DS international capacity building; DS inclusivity and society.
The main objective of the conference are:
1. Driving Research and Innovation: sharing the latest findings and advancements, to inspire researchers, scientists, and clinicians to further explore DS, develop new interventions, and improve the overall understanding of this condition.
2. Empowering Individuals and Families: Knowledge transfer is crucial to provide families with accessible information about DS and allow them to better understand the challenges and opportunities associated with DS.
3. Dissemination of scientific culture: to promote inclusive education practices. We aim to share evidence-based strategies and interventions, to help clinicians, families and educators to face diverse needs and abilities of DS people.

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