Our laboratory is comprised of a group of hard working and talented people focused on the study of neurodegenerative processes in Alzheimer Disease and Down syndrome. Our research has contributed to highlighting the role of increased oxidative stress and dysfunctional protein degradation systems in the pathogenesis and progression of Alzheimer Disease-like dementia in human samples and transgenic murine models. We have demonstrated how the oxidative modification (carbonylation, protein-bound HNE and nitration) of protein involved in proteasome and autophagy functionality are relevant in the progression of the neurodegenerative process, through conjugating redox proteomics and immunochemical methods of analysis.