Recent pubblications:

[1] M. Perluigi, F. Di Domenico, D.A. Butterfield, Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease, Physiol Rev 104(1) (2024) 103-197.

[2] C. Lanzillotta, A. Tramutola, S. Lanzillotta, V. Greco, S. Pagnotta, C. Sanchini, S. Di Angelantonio, E. Forte, S. Rinaldo, A. Paone, F. Cutruzzola, F.A. Cimini, I. Barchetta, M.G. Cavallo, A. Urbani, D.A. Butterfield, F. Di Domenico, B.D. Paul, M. Perluigi, J.M.N. Duarte, E. Barone, Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3beta, Redox Biol 73 (2024) 103221.

[3] C. Lanzillotta, M.R. Baniowska, F. Prestia, C. Sette, V. Nalesso, M. Perluigi, E. Barone, A. Duchon, A. Tramutola, Y. Herault, F. Di Domenico, Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model, Neurobiol Dis 196 (2024) 106523.

[4] A. Tramutola, S. Lanzillotta, G. Aceto, S. Pagnotta, G. Ruffolo, P. Cifelli, F. Marini, C. Ripoli, E. Palma, C. Grassi, F. Di Domenico, M. Perluigi, E. Barone, Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome, Antioxidants (Basel) 12(1) (2023).

[5] F.A. Cimini, A. Tramutola, I. Barchetta, V. Ceccarelli, E. Gangitano, S. Lanzillotta, C. Lanzillotta, M.G. Cavallo, E. Barone, Dynamic Changes of BVRA Protein Levels Occur in Response to Insulin: A Pilot Study in Humans, Int J Mol Sci 24(8) (2023).

[6] C. Vasavda, E.R. Semenza, J. Liew, R. Kothari, R.S. Dhindsa, S. Shanmukha, A. Lin, R. Tokhunts, C. Ricco, A.M. Snowman, L. Albacarys, F. Pastore, C. Ripoli, C. Grassi, E. Barone, M.D. Kornberg, X. Dong, B.D. Paul, S.H. Snyder, Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling, Sci Signal 15(733) (2022) eabh3066.

[7] M. Perluigi, A. Picca, E. Montanari, R. Calvani, F. Marini, R. Matassa, A. Tramutola, A. Villani, G. Familiari, F.D. Domenico, D.A. Butterfield, K.J. Oh, E. Marzetti, D. Valentini, E. Barone, Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles, Alzheimers Dement 18(8) (2022) 1498-1510.

[8] M. Perluigi, E. Barone, Aberrant protein networks in Alzheimer disease, Nat Rev Neurol 18(5) (2022) 255-256.

[9] S. Pagnotta, A. Tramutola, E. Barone, F. Di Domenico, V. Pittala, L. Salerno, V. Folgiero, M. Caforio, F. Locatelli, S. Petrini, D.A. Butterfield, M. Perluigi, CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome, Free Radic Biol Med 183 (2022) 1-13.

[10] F.A. Cimini, M. Perluigi, I. Barchetta, M.G. Cavallo, E. Barone, Role of Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update, Int J Mol Sci 23(10) (2022).

[11] I. Zuliani, C. Lanzillotta, A. Tramutola, A. Francioso, S. Pagnotta, E. Barone, M. Perluigi, F. Di Domenico, The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome, Neurotherapeutics 18(1) (2021) 340-363.

[12] I. Zuliani, C. Lanzillotta, A. Tramutola, E. Barone, M. Perluigi, S. Rinaldo, A. Paone, F. Cutruzzola, F. Bellanti, M. Spinelli, F. Natale, S. Fusco, C. Grassi, F. Di Domenico, High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures, Int J Mol Sci 22(7) (2021).

[13] M. Perluigi, F. Di Domenico, E. Barone, D.A. Butterfield, mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder, Free Radic Biol Med 169 (2021) 382-396.

[14] C. Lanzillotta, I. Zuliani, A. Tramutola, E. Barone, C. Blarzino, V. Folgiero, M. Caforio, D. Valentini, A. Villani, F. Locatelli, D.A. Butterfield, E. Head, M. Perluigi, J.F. Abisambra, F. Di Domenico, Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention, Prog Neurobiol 196 (2021) 101892.

[15] C. Lanzillotta, A. Tramutola, G. Di Giacomo, F. Marini, D.A. Butterfield, F. Di Domenico, M. Perluigi, E. Barone, Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome, Free Radic Biol Med 165 (2021) 152-170.

[16] C. Lanzillotta, F. Di Domenico, Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules, Biomolecules 11(2) (2021).

[17] S.A. Koren, M.J. Hamm, R. Cloyd, S.N. Fontaine, E. Chishti, C. Lanzillotta, J. Rodriguez-Rivera, A. Ingram, M. Bell, S.M. Galvis-Escobar, N. Zulia, F. Di Domenico, D. Duong, N.T. Seyfried, D. Powell, M. Vandsburger, T. Frolinger, A.M.S. Hartz, J. Koren, 3rd, J.M. Axten, N.J. Laping, J.F. Abisambra, Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy, Int J Mol Sci 22(3) (2021).

[18] E. Barone, F. Di Domenico, M. Perluigi, D.A. Butterfield, The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease, Free Radic Biol Med 176 (2021) 16-33.

[19] A. Tramutola, C. Lanzillotta, F. Di Domenico, E. Head, D.A. Butterfield, M. Perluigi, E. Barone, Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome, Neurobiol Dis 137 (2020) 104772.

[20] C. Lanzillotta, I. Zuliani, C. Vasavda, S.H. Snyder, B.D. Paul, M. Perluigi, F. Di Domenico, E. Barone, BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration, Antioxidants (Basel) 9(8) (2020).

[21] C. Lanzillotta, V. Greco, D. Valentini, A. Villani, V. Folgiero, M. Caforio, F. Locatelli, S. Pagnotta, E. Barone, A. Urbani, F. Di Domenico, M. Perluigi, Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children, Antioxidants (Basel) 9(11) (2020).