117) Tramutola, A., Pupo, G., Di Domenico, F., Barone, E., Arena, A., Lanzillotta, C., Broekaart, D., Blarzino, C., Head, E., Butterfield, D.A., Perluigi, M. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis. 2016 Mar 8
116) Tramutola, A., Di Domenico, F., Barone, E., Perluigi, M., Butterfield, D.A. It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease. Oxid Med Cell Longev. 2016;2016:2756068.
115) Klionsky, D.J., Abdelmohsen, K., Abe, A., Abedin, M.J., … Di Domenico, F., …. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.
114) Barone, E., Di Domenico, F., Cassano, T., Arena, A., Tramutola, A., Lavecchia, M.A., Coccia, R., Butterfield, D.A., Perluigi, M. Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radic Biol Med. 2016 Feb;91:127-42
113) Barone, E. Editorial: Oxidative Stress and Alzheimer Disease: Where Do We Stand?Curr Alzheimer Res. 2016;13(2):108-11.
112) Di Domenico, F., Pupo, G., Giraldo, E., Lloret, A., Badia, M.C., Schinina, M.E., Giorgi, A., Butterfield, D.A., Vina, J., Perluigi, M. Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage. Curr Alzheimer Res. 2016;13(2):112-22.
111) Di Domenico, F., Pupo, G., Giraldo, E., Badìa, M.C., Monllor, P., Lloret, A., Schininà, E.M., Giorgi, A., Cini, C., Tramutola, A., Butterfield, D.A., Viña, J., Perluigi, M. Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients. Free Radic Biol Med. 2016 Feb;91:1-9
110) Tramutola, A., Lanzillotta, C., Arena, A., Barone, E., Perluigi, M., Di Domenico, F. Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down’s Syndrome. Neurodegener Dis. 2016;16(1-2):62-8.
109) Triplett, J.C., Tramutola, A., Swomley, A., Kirk, J., Grimes, K., Lewis, K., Orr, M., Rodriguez, K., Cai, J., Klein, J.B., Perluigi, M., Buffenstein, R., Butterfield, D.A. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2213-24
108) Bedse, G., Di Domenico, F., Serviddio, G., Cassano, T. Aberrant insulin signaling in Alzheimer’s disease: current knowledge. Front Neurosci. 2015 Jun 16;9:204
107) Nenna, A., Nappi, F., Avatar Singh, S.S., Sutherland, F.W., Di Domenico, F., Chello, M., Spadaccio, C. Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease. Res Cardiovasc Med. 2015 May 23;4(2):e26949.
106) Barone, E., Cenini, G., Di Domenico, F., Noel, T., Wang, C., Perluigi, M., St Clair, D.K., Butterfield, D.A. Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53.J Neurosci Res. 2015 Nov;93(11):1728-39
105) Di Domenico, F., Perluigi, M., Butterfield, D.A. Redox Proteomics in Human Biofluids: Sample Preparation, Separation and Immunochemical Tagging for Analysis of Protein Oxidation. Methods Mol Biol. 2016;1303:391-403
104) Barone, E., Butterfield, D.A. Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille’s heel? Neurobiol Dis. 2015 Dec;84:69-77.
103) Perluigi, M., Di Domenico, F. and Butterfield D.A., mTor signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairement of autophagy. Neurobiol Dis. 2015 doi: 10.1016/j.nbd.2015.03.014
102) Barone, E., Butterfield, D.A., Insulin resistance in Alzheimer Disease: Is Heme oxygenase 1 an Achille’s heel?. Neurobiol Dis. 2015 doi: 10.1016/j.nbd.2015.02.013.
101) Tramutola, A., J.C. Triplett, F. Di Domenico, D.M. Niedowicz, M.P. Murphy, R. Coccia, M. Perluigi, and D.A. Butterfield, Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. J Neurochem, 2015 Jun;133(5):739-49.
100) Giovagnoli, S., T. Cassano, L. Pace, A. Magini, A. Polchi, B. Tancini, M. Perluigi, F. De Marco, C. Emiliani, and D. Dolcetta, Evaluation of a LC-MS method for everolimus preclinical determination in brain by using [(13)C2D4]RAD001 internal standard. J Chromatogr B Analyt Technol Biomed Life Sci, 2015. 985: p. 155-63.
99) Di Domenico, F., G. Pupo, C. Mancuso, E. Barone, F. Paolini, A. Arena, C. Blarzino, F.A. Schmitt, E. Head, D.A. Butterfield, and M. Perluigi, Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer’s Disease. J Alzheimers Dis, 2015. 44(4): p. 1107-20.
98) Di Domenico, F., E. Barone, M. Perluigi, and D.A. Butterfield, Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants. Expert Rev Neurother, 2015. 15(1): p. 19-40.
97) Spadaccio, C., F. De Marco, F. Di Domenico, R. Coccia, M. Lusini, R. Barbato, E. Covino, and M. Chello, Simvastatin attenuates the endothelial pro-thrombotic shift in saphenous vein grafts induced by Advanced glycation endproducts. Thromb Res, 2014. 133(3): p. 418-25.
96) Perluigi, M., A.M. Swomley, and D.A. Butterfield, Redox proteomics and the dynamic molecular landscape of the aging brain. Ageing Res Rev, 2014. 13: p. 75-89.
95) Perluigi, M., G. Pupo, A. Tramutola, C. Cini, R. Coccia, E. Barone, E. Head, D.A. Butterfield, and F. Di Domenico, Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta, 2014. 1842(7): p. 1144-53.
94) Perluigi, M., F. Di Domenico, and D.A. Buttterfield, Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics. Proteomics Clin Appl, 2014. 8(1-2): p. 73-85.
93) Foppoli, C., F. De Marco, C. Cini, and M. Perluigi, Redox control of viral carcinogenesis: The human papillomavirus paradigm. Biochim Biophys Acta, 2014.
92) Di Domenico, F., G. Pupo, A. Tramutola, A. Giorgi, M.E. Schinina, R. Coccia, E. Head, D.A. Butterfield, and M. Perluigi, Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med, 2014. 71: p. 270-80.
91) Cenini, G., A. Fiorini, R. Sultana, M. Perluigi, J. Cai, J.B. Klein, E. Head, and D.A. Butterfield, An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Free Radic Biol Med, 2014. 76: p. 89-95.
90) Butterfield, D.A., L. Gu, F. Di Domenico, and R.A. Robinson, Mass spectrometry and redox proteomics: applications in disease. Mass Spectrom Rev, 2014. 33(4): p. 277-301.
89) Butterfield, D.A., F. Di Domenico, A.M. Swomley, E. Head, and M. Perluigi, Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down’s syndrome and Alzheimer’s disease brain. Biochem J, 2014. 463(2): p. 177-89.
88) Butterfield, D.A., F. Di Domenico, and E. Barone, Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. Biochim Biophys Acta, 2014. 1842(9): p. 1693-706.
87) Barone, E., S. Mosser, and P.C. Fraering, Inactivation of brain Cofilin-1 by age, Alzheimer’s disease and gamma-secretase. Biochim Biophys Acta, 2014. 1842(12 Pt A): p. 2500-9.
86) Barone, E., F. Di Domenico, C. Mancuso, and D.A. Butterfield, The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it’s time for reconciliation. Neurobiol Dis, 2014. 62: p. 144-59.
85) Barone, E., F. Di Domenico, and D.A. Butterfield, Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets. Biochem Pharmacol, 2014. 88(4): p. 605-16.
84) Trombino, S., R. Cassano, T. Ferrarelli, E. Barone, N. Picci, and C. Mancuso, Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes. Colloids Surf B Biointerfaces, 2013. 109: p. 273-9.
83) Sultana, R., M. Perluigi, and D. Allan Butterfield, Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain. Free Radic Biol Med, 2013. 62: p. 157-69.
82) Spadaccio, C., G. Patti, F. De Marco, R. Coccia, F. Di Domenico, F. Pollari, R. Zanzonico, M. Pettinari, M. Lusini, G. Di Sciascio, E. Covino, and M. Chello, Usefulness of preprocedural levels of advanced glycation end products to predict restenosis in patients with controlled diabetes mellitus undergoing drug-eluting stent implantation for stable angina pectoris (from the Prospective ARMYDA-AGEs Study). Am J Cardiol, 2013. 112(1): p. 21-6.
81) Fiorini, A., R. Sultana, S. Forster, M. Perluigi, G. Cenini, C. Cini, J. Cai, J.B. Klein, S.A. Farr, M.L. Niehoff, J.E. Morley, V.B. Kumar, and D. Allan Butterfield, Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study. Free Radic Biol Med, 2013. 65: p. 1-14.
80) Fiorini, A., T. Koudriavtseva, E. Bucaj, R. Coccia, C. Foppoli, A. Giorgi, M.E. Schinina, F. Di Domenico, F. De Marco, and M. Perluigi, Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis. PLoS One, 2013. 8(6): p. e65184.
79) Di Domenico, F., M. Perluigi, and E. Barone, Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain. Neural Regen Res, 2013. 8(21): p. 1925-37.
78) Di Domenico, F., F. De Marco, and M. Perluigi, Proteomics strategies to analyze HPV-transformed cells: relevance to cervical cancer. Expert Rev Proteomics, 2013. 10(5): p. 461-72.
77) Di Domenico, F., R. Coccia, A. Cocciolo, M.P. Murphy, G. Cenini, E. Head, D.A. Butterfield, A. Giorgi, M.E. Schinina, C. Mancuso, C. Cini, and M. Perluigi, Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer’s disease neuropathology: redox proteomics analysis of human brain. Biochim Biophys Acta, 2013. 1832(8): p. 1249-59.
76) Spadaccio, C., F. Di Domenico, M. Perluigi, M. Lusini, A. Giorgi, M.E. Schinina, C. Blarzino, E. Covino, M. Chello, and R. Coccia, Serum proteomics in patients with diagnosis of abdominal aortic aneurysm. Cardiovasc Pathol, 2012. 21(4): p. 283-90.
75) Perluigi, M., R. Coccia, and D.A. Butterfield, 4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies. Antioxid Redox Signal, 2012. 17(11): p. 1590-609.
74) Perluigi, M. and D.A. Butterfield, Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia. Curr Gerontol Geriatr Res, 2012. 2012: p. 724904.
73) Mancuso, C., R. Siciliano, E. Barone, and P. Preziosi, Natural substances and Alzheimer’s disease: from preclinical studies to evidence based medicine. Biochim Biophys Acta, 2012. 1822(5): p. 616-24.
72) Mancuso, C., E. Barone, P. Guido, F. Miceli, F. Di Domenico, M. Perluigi, R. Santangelo, and P. Preziosi, Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro. Neurosci Lett, 2012. 518(2): p. 101-5.
71) Keeney, J.T., A.M. Swomley, J.L. Harris, A. Fiorini, M.I. Mitov, M. Perluigi, R. Sultana, and D.A. Butterfield, Cell cycle proteins in brain in mild cognitive impairment: insights into progression to Alzheimer disease. Neurotox Res, 2012. 22(3): p. 220-30.
70) Fiorini, A., R. Sultana, E. Barone, G. Cenini, M. Perluigi, C. Mancuso, J. Cai, J.B. Klein, D. St Clair, and D.A. Butterfield, Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53. PLoS One, 2012. 7(11): p. e49846.
69) Di Domenico, F., R. Sultana, A. Ferree, K. Smith, E. Barone, M. Perluigi, R. Coccia, W. Pierce, J. Cai, C. Mancuso, R. Squillace, M. Wiengele, I. Dalle-Donne, B. Wolozin, and D.A. Butterfield, Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease. Antioxid Redox Signal, 2012. 17(11): p. 1490-506.
68) Di Domenico, F., C. Foppoli, R. Coccia, and M. Perluigi, Antioxidants in cervical cancer: chemopreventive and chemotherapeutic effects of polyphenols. Biochim Biophys Acta, 2012. 1822(5): p. 737-47.
67) Di Domenico, F., G. Casalena, J. Jia, R. Sultana, E. Barone, J. Cai, W.M. Pierce, C. Cini, C. Mancuso, M. Perluigi, C.M. Davis, N.J. Alkayed, and D.A. Butterfield, Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion. J Neurochem, 2012. 121(4): p. 680-92.
66) Di Domenico, F., E. Barone, C. Mancuso, M. Perluigi, A. Cocciolo, P. Mecocci, D.A. Butterfield, and R. Coccia, HO-1/BVR-a system analysis in plasma from probable Alzheimer’s disease and mild cognitive impairment subjects: a potential biochemical marker for the prediction of the disease. J Alzheimers Dis, 2012. 32(2): p. 277-89.
65) De Marco, F., E. Bucaj, C. Foppoli, A. Fiorini, C. Blarzino, K. Filipi, A. Giorgi, M.E. Schinina, F. Di Domenico, R. Coccia, D.A. Butterfield, and M. Perluigi, Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues. PLoS One, 2012. 7(3): p. e34366.
64) Cocciolo, A., F. Di Domenico, R. Coccia, A. Fiorini, J. Cai, W.M. Pierce, P. Mecocci, D.A. Butterfield, and M. Perluigi, Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics. Free Radic Biol Med, 2012. 53(10): p. 1868-76.
63) Cenini, G., A.L. Dowling, T.L. Beckett, E. Barone, C. Mancuso, M.P. Murphy, H. Levine, 3rd, I.T. Lott, F.A. Schmitt, D.A. Butterfield, and E. Head, Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta, 2012. 1822(2): p. 130-8.
62) Butterfield, D.A., M. Perluigi, T. Reed, T. Muharib, C.P. Hughes, R.A. Robinson, and R. Sultana, Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications. Antioxid Redox Signal, 2012. 17(11): p. 1610-55.
61) Butterfield, D.A., E. Barone, F. Di Domenico, G. Cenini, R. Sultana, M.P. Murphy, C. Mancuso, and E. Head, Atorvastatin treatment in a dog preclinical model of Alzheimer’s disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol, 2012. 15(7): p. 981-7.
60) Barone, E., C. Mancuso, F. Di Domenico, R. Sultana, M.P. Murphy, E. Head, and D.A. Butterfield, Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem, 2012. 120(1): p. 135-46.
59) Barone, E., F. Di Domenico, R. Sultana, R. Coccia, C. Mancuso, M. Perluigi, and D.A. Butterfield, Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med, 2012. 52(11-12): p. 2292-301.
58) Barone, E., G. Cenini, R. Sultana, F. Di Domenico, A. Fiorini, M. Perluigi, T. Noel, C. Wang, C. Mancuso, D.K. St Clair, and D.A. Butterfield, Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B. Antioxid Redox Signal, 2012. 16(12): p. 1407-20.
57) Sultana, R., R.A. Robinson, F. Di Domenico, H.M. Abdul, D.K. St Clair, W.R. Markesbery, J. Cai, W.M. Pierce, and D.A. Butterfield, Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. J Proteomics, 2011. 74(11): p. 2430-40.
56) Siciliano, R., E. Barone, V. Calabrese, V. Rispoli, D.A. Butterfield, and C. Mancuso, Experimental research on nitric oxide and the therapy of Alzheimer disease: a challenging bridge. CNS Neurol Disord Drug Targets, 2011. 10(7): p. 766-76.
55) Perluigi, M., F. di Domenico, A. Fiorini, A. Cocciolo, A. Giorgi, C. Foppoli, D.A. Butterfield, M. Giorlandino, C. Giorlandino, M.E. Schinina, and R. Coccia, Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid. Proteomics Clin Appl, 2011. 5(3-4): p. 167-78.
54) Perluigi, M. and D.A. Butterfield, The identification of protein biomarkers for oxidative stress in Down syndrome. Expert Rev Proteomics, 2011. 8(4): p. 427-9.
53) Martin, S.B., G. Cenini, E. Barone, A.L. Dowling, C. Mancuso, D.A. Butterfield, M.P. Murphy, and E. Head, Coenzyme Q10 and cognition in atorvastatin treated dogs. Neurosci Lett, 2011. 501(2): p. 92-5.
52) Mancuso, C., R. Siciliano, E. Barone, D.A. Butterfield, and P. Preziosi, Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before. Expert Opin Investig Drugs, 2011. 20(9): p. 1243-61.
51) Mancuso, C., R. Siciliano, and E. Barone, Curcumin and Alzheimer disease: this marriage is not to be performed. J Biol Chem, 2011. 286(3): p. le3; author reply le4.
50) Di Domenico, F., R. Sultana, E. Barone, M. Perluigi, C. Cini, C. Mancuso, J. Cai, W.M. Pierce, and D.A. Butterfield, Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer’s disease subjects. J Proteomics, 2011. 74(7): p. 1091-103.
49) Di Domenico, F., R. Coccia, D.A. Butterfield, and M. Perluigi, Circulating biomarkers of protein oxidation for Alzheimer disease: expectations within limits. Biochim Biophys Acta, 2011. 1814(12): p. 1785-95.
48) Butterfield, D.A., E. Barone, and C. Mancuso, Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders. Pharmacol Res, 2011. 64(3): p. 180-6.
47) Barone, E., F. Di Domenico, G. Cenini, R. Sultana, R. Coccia, P. Preziosi, M. Perluigi, C. Mancuso, and D.A. Butterfield, Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer’s disease and amnestic mild cognitive impairment. J Alzheimers Dis, 2011. 25(4): p. 623-33.
46) Barone, E., F. Di Domenico, G. Cenini, R. Sultana, C. Cini, P. Preziosi, M. Perluigi, C. Mancuso, and D.A. Butterfield, Biliverdin reductase–a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment. Biochim Biophys Acta, 2011. 1812(4): p. 480-7.
45) Barone, E., G. Cenini, F. Di Domenico, S. Martin, R. Sultana, C. Mancuso, M.P. Murphy, E. Head, and D.A. Butterfield, Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res, 2011. 63(3): p. 172-80.
44) Sultana, R., M. Perluigi, S.F. Newman, W.M. Pierce, C. Cini, R. Coccia, and D.A. Butterfield, Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer’s disease. Antioxid Redox Signal, 2010. 12(3): p. 327-36.
43) Sultana, R., F. Di Domenico, M. Tseng, J. Cai, T. Noel, R.L. Chelvarajan, W.D. Pierce, C. Cini, S. Bondada, D.K. St Clair, and D.A. Butterfield, Doxorubicin-induced thymus senescence. J Proteome Res, 2010. 9(12): p. 6232-41.
42) Perluigi, M., F. Di Domenico, A. Giorgi, M.E. Schinina, R. Coccia, C. Cini, F. Bellia, M.T. Cambria, C. Cornelius, D.A. Butterfield, and V. Calabrese, Redox proteomics in aging rat brain: involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process. J Neurosci Res, 2010. 88(16): p. 3498-507.
41) Perluigi, M., F. Di Domenico, C. Blarzino, C. Foppoli, C. Cini, A. Giorgi, C. Grillo, F. De Marco, D.A. Butterfield, M.E. Schinina, and R. Coccia, Effects of UVB-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach. Proteome Sci, 2010. 8: p. 13.
40) Fetoni, A.R., C. Mancuso, S.L. Eramo, M. Ralli, R. Piacentini, E. Barone, G. Paludetti, and D. Troiani, In vivo protective effect of ferulic acid against noise-induced hearing loss in the guinea-pig. Neuroscience, 2010. 169(4): p. 1575-88.
39) Errico, S., R. Shohreh, E. Barone, A. Pusateri, N. Mores, and C. Mancuso, Heme oxygenase-derived carbon monoxide modulates gonadotropin-releasing hormone release in immortalized hypothalamic neurons. Neurosci Lett, 2010. 471(3): p. 175-8.
38) Di Domenico, F., R. Sultana, G.F. Tiu, N.N. Scheff, M. Perluigi, C. Cini, and D.A. Butterfield, Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: an investigation on the role of cellular stress response in the progression of Alzheimer disease. Brain Res, 2010. 1333: p. 72-81.
37) Di Domenico, F., M. Perluigi, D.A. Butterfield, C. Cornelius, and V. Calabrese, Oxidative damage in rat brain during aging: interplay between energy and metabolic key target proteins. Neurochem Res, 2010. 35(12): p. 2184-92.
36) Di Domenico, F., J.B. Owen, R. Sultana, R.A. Sowell, M. Perluigi, C. Cini, J. Cai, W.M. Pierce, and D.A. Butterfield, The wheat germ agglutinin-fractionated proteome of subjects with Alzheimer’s disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression. J Neurosci Res, 2010. 88(16): p. 3566-77.
35) Di Domenico, F., G. Casalena, R. Sultana, J. Cai, W.M. Pierce, M. Perluigi, C. Cini, A. Baracca, G. Solaini, G. Lenaz, J. Jia, S. Dziennis, S.J. Murphy, N.J. Alkayed, and D.A. Butterfield, Involvement of Stat3 in mouse brain development and sexual dimorphism: a proteomics approach. Brain Res, 2010. 1362: p. 1-12.
34) Sultana, R., M. Perluigi, and D.A. Butterfield, Proteomics identification of oxidatively modified proteins in brain. Methods Mol Biol, 2009. 564: p. 291-301.
33) Sultana, R., M. Perluigi, and D.A. Butterfield, Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis. Acta Neuropathol, 2009. 118(1): p. 131-50.
32) Perluigi, M., R. Sultana, G. Cenini, F. Di Domenico, M. Memo, W.M. Pierce, R. Coccia, and D.A. Butterfield, Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer’s disease: Role of lipid peroxidation in Alzheimer’s disease pathogenesis. Proteomics Clin Appl, 2009. 3(6): p. 682-693.
31) Perluigi, M., A. Giorgi, C. Blarzino, F. De Marco, C. Foppoli, F. Di Domenico, D.A. Butterfield, M.E. Schinina, C. Cini, and R. Coccia, Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation. J Cell Mol Med, 2009. 13(8B): p. 1809-22.
30) Perluigi, M., F. Di Domenico, C. Cini, R. Coccia, F.R. Giorlandino, M. Giorlandino, P. Cignini, A. Mesoraca, and C. Giorlandino, Proteomic analysis for the study of amniotic fluid protein composition. J Prenat Med, 2009. 3(3): p. 39-41.
29) Owen, J.B., F. Di Domenico, R. Sultana, M. Perluigi, C. Cini, W.M. Pierce, and D.A. Butterfield, Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer’s disease and mild cognitive impairment: implications for progression of AD. J Proteome Res, 2009. 8(2): p. 471-82.
28) Mastromarino, P., S. Macchia, L. Meggiorini, V. Trinchieri, L. Mosca, M. Perluigi, and C. Midulla, Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect, 2009. 15(1): p. 67-74.
27) Di Domenico, F., M. Perluigi, C. Foppoli, C. Blarzino, R. Coccia, F. De Marco, D.A. Butterfield, and C. Cini, Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes. Free Radic Res, 2009. 43(4): p. 365-75.
26) Di Domenico, F., C. Foppoli, C. Blarzino, M. Perluigi, F. Paolini, S. Morici, R. Coccia, C. Cini, and F. De Marco, Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity. J Exp Clin Cancer Res, 2009. 28: p. 4.
25) Di Domenico, F., G. Cenini, R. Sultana, M. Perluigi, D. Uberti, M. Memo, and D.A. Butterfield, Glutathionylation of the pro-apoptotic protein p53 in Alzheimer’s disease brain: implications for AD pathogenesis. Neurochem Res, 2009. 34(4): p. 727-33.
24) Reed, T., M. Perluigi, R. Sultana, W.M. Pierce, J.B. Klein, D.M. Turner, R. Coccia, W.R. Markesbery, and D.A. Butterfield, Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer’s disease. Neurobiol Dis, 2008. 30(1): p. 107-20.
23) Sultana, R., T. Reed, M. Perluigi, R. Coccia, W.M. Pierce, and D.A. Butterfield, Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study. J Cell Mol Med, 2007. 11(4): p. 839-51.
22) Newman, S.F., R. Sultana, M. Perluigi, R. Coccia, J. Cai, W.M. Pierce, J.B. Klein, D.M. Turner, and D.A. Butterfield, An increase in S-glutathionylated proteins in the Alzheimer’s disease inferior parietal lobule, a proteomics approach. J Neurosci Res, 2007. 85(7): p. 1506-14.
21) De Marco, F., M. Perluigi, C. Foppoli, C. Blarzino, C. Cini, R. Coccia, and A. Venuti, UVB irradiation down-regulates HPV-16 RNA expression: implications for malignant progression of transformed cells. Virus Res, 2007. 130(1-2): p. 249-59.
20) Coccia, R., C. Spadaccio, C. Foppoli, M. Perluigi, E. Covino, M. Lusini, and M. Chello, The effect of simvastatin on erythrocyte membrane fluidity during oxidative stress induced by cardiopulmonary bypass: a randomized controlled study. Clin Ther, 2007. 29(8): p. 1706-17.
19) Calabrese, V., C. Mancuso, A. Ravagna, M. Perluigi, C. Cini, C. De Marco, D.A. Butterfield, and A.M. Stella, In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state. J Neurochem, 2007. 101(3): p. 709-17.
18) Butterfield, D.A., T.T. Reed, M. Perluigi, C. De Marco, R. Coccia, J.N. Keller, W.R. Markesbery, and R. Sultana, Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer’s disease. Brain Res, 2007. 1148: p. 243-8.
17) Sultana, R., M. Perluigi, and D.A. Butterfield, Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer’s disease: insights into mechanism of neurodegeneration from redox proteomics. Antioxid Redox Signal, 2006. 8(11-12): p. 2021-37.
16) Sultana, R., M. Perluigi, and D.A. Butterfield, Redox proteomics identification of oxidatively modified proteins in Alzheimer’s disease brain and in vivo and in vitro models of AD centered around Abeta(1-42). J Chromatogr B Analyt Technol Biomed Life Sci, 2006. 833(1): p. 3-11.
15) Perluigi, M., G. Joshi, R. Sultana, V. Calabrese, C. De Marco, R. Coccia, C. Cini, and D.A. Butterfield, In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress. J Neurosci Res, 2006. 84(2): p. 418-26.
14) Perluigi, M., G. Joshi, R. Sultana, V. Calabrese, C. De Marco, R. Coccia, and D.A. Butterfield, In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress. Neuroscience, 2006. 138(4): p. 1161-70.
13) Mancuso, C., M. Perluigi, C. Cini, C. De Marco, A.M. Giuffrida Stella, and V. Calabrese, Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay. J Neurosci Res, 2006. 84(7): p. 1385-91.
12) Joshi, G., M. Perluigi, R. Sultana, R. Agrippino, V. Calabrese, and D.A. Butterfield, In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders. Neurochem Int, 2006. 48(4): p. 318-27.
11) Butterfield, D.A., T. Reed, M. Perluigi, C. De Marco, R. Coccia, C. Cini, and R. Sultana, Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment. Neurosci Lett, 2006. 397(3): p. 170-3.
10) Butterfield, D.A., M. Perluigi, and R. Sultana, Oxidative stress in Alzheimer’s disease brain: new insights from redox proteomics. Eur J Pharmacol, 2006. 545(1): p. 39-50.
9) Perluigi, M., H.F. Poon, W. Maragos, W.M. Pierce, J.B. Klein, V. Calabrese, C. Cini, C. De Marco, and D.A. Butterfield, Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington disease. Mol Cell Proteomics, 2005. 4(12): p. 1849-61.
8) Perluigi, M., H. Fai Poon, K. Hensley, W.M. Pierce, J.B. Klein, V. Calabrese, C. De Marco, and D.A. Butterfield, Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice–a model of familial amyotrophic lateral sclerosis. Free Radic Biol Med, 2005. 38(7): p. 960-8.
7) Joshi, G., R. Sultana, M. Perluigi, and D.A. Butterfield, In vivo protection of synaptosomes from oxidative stress mediated by Fe2+/H2O2 or 2,2-azobis-(2-amidinopropane) dihydrochloride by the glutathione mimetic tricyclodecan-9-yl-xanthogenate. Free Radic Biol Med, 2005. 38(8): p. 1023-31.
6) Foppoli, C., F. De Marco, C. Blarzino, M. Perluigi, C. Cini, and R. Coccia, Biological response of human diploid keratinocytes to quinone-producing compounds: role of NAD(P)H:quinone oxidoreductase 1. Int J Biochem Cell Biol, 2005. 37(4): p. 852-63.
5) De Marco, F., C. Foppoli, R. Coccia, C. Blarzino, M. Perluigi, C. Cini, and M.L. Marcante, Ectopic deposition of melanin pigments as detoxifying mechanism: a paradigm for basal nuclei pigmentation. Biochem Biophys Res Commun, 2004. 314(2): p. 631-7.
4) Perluigi, M., F. De Marco, C. Foppoli, R. Coccia, C. Blarzino, M.L. Marcante, and C. Cini, Tyrosinase protects human melanocytes from ROS-generating compounds. Biochem Biophys Res Commun, 2003. 305(2): p. 250-6.
3) Mosca, L., S. Marcellini, M. Perluigi, P. Mastroiacovo, S. Moretti, G. Famularo, I. Peluso, G. Santini, and C. De Simone, Modulation of apoptosis and improved redox metabolism with the use of a new antioxidant formula. Biochem Pharmacol, 2002. 63(7): p. 1305-14.
2) De Marco, F., M. Perluigi, M.L. Marcante, R. Coccia, C. Foppoli, C. Blarzino, and M.A. Rosei, Cytotoxicity of dopamine-derived tetrahydroisoquinolines on melanoma cells. Biochem Pharmacol, 2002. 64(10): p. 1503-12.
1) Famularo, G., M. Perluigi, R. Coccia, P. Mastroiacovo, and C. De Simone, Microecology, bacterial vaginosis and probiotics: perspectives for bacteriotherapy. Med Hypotheses, 2001. 56(4): p. 421-30.
